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Resolve Chronic Inflammation and Achieve Healthy Ageing by Understanding Non-regenerative Repair

Joint Publication

Carloni A, Poletti V, Fermo L, Bellomo N, Chilosi M. (2013) Heterogeneous distribution of mechanical stress in human lung: A mathematical approach to evaluate abnormal remodeling in IPF. J. Theor Biol., 332(2013)136–140. doi: 10.1016/j.jtbi.2013.04.038

Lemieszek M, Chilosi M, Golec M, Skórska C, Dinnyes A, Mashayekhi K, Vierlinger K, Huaux F, Wielscher M, Hofner M, Yakoub Y, Pastena C, Daniele I, Cholewa G, Sitkowska J, Lisowska W, Zwolinski J, Milanowski J, Mackiewicz B, Góra-Florek A, Ziesche R, Dutkiewicz J. (2013). Age influence on hypersensitivity pneumonitis induced in mice by exposure to Pantoea agglomerans. Inhalation Toxicology, 25(11), 640-650.

Ziesche R, Golec M, Samaha E. (2013). The RESOLVE concept – Approaching pathophysiology of fibroproliferative disease in aged individuals. Biogerontology, (accepted for printing).

Caporali A, Meloni M, Miller AM, Vierlinger K, Cardinal A, Spinetti G, Faglia E, Losa S, Gotti A, Fortunato O, Hofner M, Noehammer C, Madeddu P, Emanueli C (2012)..Soluble ST2 is regulated by p75NTR and predicts mortality in diabetic patients with critical limb ischemia. Arterioscler Thromb Vasc Biol. 32(12): e149-60. doi: 10.1161/ATVBAHA.

Gröger CJ, Grubinger G, Waldhör T, Vierlinger K, Mikulits, W. (2012). Meta-analysis of gene expression signatures defining the epithelial to mesenchymal transition during cancer progression. PLos One, 7(12):e51136.

Femo L, Bellomo N, Lumenta DB. (2011) Assessment of surgical strategies for addressing keloids: a mathematical optimization problem. Comput Math Appl., 62(6):2417-2423.

Lemieszek M, Chilosi M, Golec M, Skórska C, Huaux F, Yakoub Y, Pastena C, Daniele I, Cholewa G, Sitkowska J, Lisowska W, Zwolinski J. Milanowski J. Mackiewicz B, Góra A, Dutkiewicz J. (2011) Mouse model of hypersensitivity pneumonitis after inhalation exposure to different microbial antigens associated with organic dusts. Ann Agric Environ Med., 18(1):159-68.

van Zijl F, Mall S, Machat G, Pirker C, Zeillinger R, Weinhaeusel A, Bilban M, Berger W, Mikulits W. (2011) A Human Model of Epithelial to Mesenchymal Transition to Monitor Drug Efficacy in Hepatocellular Carcinoma Progression. Mol Cancer Ther., 10(5):850-60.

Vazquez M, Carmona-Saez P, Nogales R, Chagoyen M, Tirado F, Carazo JM, Pascual-Montano A. (2009) SENT: Semantic Features in Text. Nucleic Acids Research, 37(Web Server issue):W153-9. Epub.

Nogales R, Carmona-Saez P, Vazquez M, Tirado F, Carazo JM, Pascual-Montano A. (2009) GeneCodis: interpreting gene lists through enrichment analysis and integration of diverse biological information. Nucleic Acids Research, doi: 10.1093/nar/gkp416.

Golec M, Lambers C, Hofbauer E, Geleff S, Bankier A, Czerny M, Ziesche R. (2008) Assessment of Gene Transcription Demonstrates Connection with the Clinical Course of Idiopathic Interstitial Pneumonia. Respiration, 76(3):261-9.

 

Individual Publications

Nicola Bellomo

Bellouquid A., De Angelis E., and Knopoff D. (2013). From the modeling of the hallmarks of cancer to a black swan in biology, Mathematical Models and Methods in Applied Sciences, 23, 949-978.

Bellomo N. and Soler J. (2012). On the mathematical theory of the dynamics of swarms viewed as a complex system, Mathematical Models Methods Applied Sciences, 22 (Supp01), Paper No. 1140006.

Arlotti L.,De Angelis E., Fermo L., Lachowicz M., and Bellomo N. (2012)., On a Class of Integro-Differential Equations Modeling Complex Systems with Nonlinear Interactions, Applied Mathematics Letters, 25 (2012), 490-495.

Femo L, Bellomo N. (2012) Report on Simulation Software for Biological Problems studied in RESOLVE.

N. Bellomo, A. Bellouquid, J. Nieto, J. Soler. (2012) On the asymptotic theory from microscopic to macroscopic growing tissue models: an overview with perspectives, Math. Models Methods Appl. Sci., 22(1).

N. Bellomo, F. Brezzi. (2011) Mathematics and complexity in biological sciences, Math. Models Methods Appl. Sci., 21(1 supp):819-824.

Bellomo N, Carbonaro B. (2011) Looking for a mathematics for living systems: Reply to comments on "Towards a mathematical theory of living systems focusing on developmental biology and evolution: A review and perspectives". Phys. Life Rev., 8(1):33-38.

Bellomo N, Carbonaro B. (2011) Toward a mathematical theory of living systems focusing on developmental biology and evolution: A review and perspectives. Phys. Life Rev., 8(1):1-18.

Bianca C, Bellomo N. (2011) Towards a Mathematical Theory of Complex Biological Systems. World Scientific Publishing.

Bianca C, Fermo L. (2011) Bifurcation diagrams for the moments of a kinetic type model of keloid-immune system competition. Comput. Math. Appl., 61(2):277-288.

Bianca C. (2011) Mathematical modeling for keloid formation triggered by virus: malignant effects and immune system competition. Math. Models Methods Appl. Sci., 21(2): 389-419.

Bellomo N. (2010) Modeling the hiding-learning dynamics in large living systems. Appl. Math. Lett., 23(8):907-911.

Bellomo N, Bellouquid A, Nieto J, Soler J. (2010) Complexity and mathematical tools toward the modelling of multicellular growing systems. Math. Comput. Modelling, 51(5-6):441-451.

Bellomo N, Bellouquid A, Nieto J, Soler J. (2010) Multiscale biological tissue models and flux-limited chemotaxis for multicellular growing systems. Math. Models Methods Appl. Sci., 20(7):1179-1207.

Bellomo N, Bianca C, Mongiově MS. (2010) On the modeling of nonlinear interactions in large complex systems. Appl. Math. Lett., 23(11):1372-1377.

Bellomo N, Bianca C, Delitala M. (2009) Complexity Analysis and Mathematical Tools Towards the Modelling of Living Systems. Physics of Life Reviews, 6 (2009), 144-175.

Bellomo N, Bellouquid A. (2009) On the derivation of macroscopic hyperbolic equations for binary multicellular growing mixtures. Computers Mathematics with Applications, 57, 744-756.

Bellomo N, Delitala M. (2009) On the coupling of higher and lower scales by the mathematical kinetic theory of active particles. Applied Mathematical Letters, 22, 646-650.

Bellomo N, Delitala M. (2008) From the Mathematical Kinetic, and Stochastic Game Theory to Modelling Mutations, Onset, Progression and Immune Competition of Cancer Cells. Physics of Life Reviews, 5, 183-206.

José Maria Carazo

Vazquez M, Nogales-Cadenas R, Arroyo J, Botías P, García R, Carazo JM, Tirado F, Pascual-Montano A, Carmona-Saez P. (2010) MARQ: an online tool to mine GEO for experiments with similar or opposite gene expression signatures. Nucleic Acids Res., 38(Web Server issue):W228-32.

Neves ML, Carazo JM, Pascual-Montano A. (2010) Moara: a Java library for extracting and normalizing gene and protein mentions. BMC Bioinformatics, 11:157.

Marco Chilosi

Chilosi M, Carloni A, Rossi A, Poletti V. (2013). Premature lung aging and cellular senescence in the pathogenesis of idiopathic pulmonary fibrosis and COPD/emphysema. Transl Res. 162(3):156-73. doi: 10.1016/j.trsl.2013.06.004.

Chilosi M, Polett V, Rossi A. (2012) The pathogenesis of COPD and IPF: Distinct horns of the same devil? Respir Res. 11;13:3.

Reghellin D, Murer B, Poletti V, Tomassetti S, Cavazza L, Rossi G, Pelosi G, Pedron S, Montagna L, Piccoli P, Chilosi M. (2009) Cathepsin-K Immunohistochemistry in the sensitive and specific detection of Micro-Granulomas in the Hypersensitivity Pneumonitis. Sarcoidosis Vasc Diffuse Lung Dis., 27(1):57-63.

Chilosi M, Pea M, Martignoni G, Brunelli M, Gobbo S, Poletti V, Bonetti F. (2008) Cathepsin-k expression in pulmonary lymphangioleiomyomatosis. Mod Pathol., 22(2), 161-6.

András Dinnyés

Rungarunlert S, Klincumhom N, Bock I, Nemes Cs, Techakumphu M, Pirity M, Dinnyes A. (2011) Enhanced cardiac differentiation of mouse embryonic stem cells by use of the slow turning lateral vessel (STLV) bioreactor, Section: Animal Cell Technology. Biotechnology Letters, 33(8): p. 1565-73.

Mamo S, Kobolak J, Borbíró I, Bíró T, Bock I, Dinnyes A. (2010) Gene targeting and Calcium handling efficiencies in mouse embryonic stem cell lines. World Journal Stem Cells, 2(6), 127-140.

Varga E, Nemes C, Klincumhom N, Polgar Z, Muenthaisong S, Ujhelly O, Pirity M, Dinnyes A. (2011) Generation of mouse induced pluripotent stem cells from different genetic backgrounds by excisable lentiviral system, ISSCR meeting, Toronto.

Polgar Z,Tar K, Rungarunlert S, Muenthaisong S, Bock I, Pirity M, Dinnyes A. (2009) Improved derivation of embryonic stem cell lines from inbred c57BL/6J mouse strains. Proceeedings of the ISCCR 7th Annual Meeting. Barcelona, Spain, July 8-9, 2009. p. 104.

Conference Proceedings:

Carstea AC, Polgar Z, Kovacs L, Dinnyes A. (2011) The efficiency of intracytoplasmic sperm injection v. laser-assisted in vitro fertilization with frozen sperm for recovery transgenic C57BL/6 mouse strains, Proceedings of IETS 37th Annual Conference, Jan 2011 Orlando, USA Reproduction, Fertility and Development. 23:240.

Pirity M, Dinnyés A. (2010) Transzgenetikus és knock out állatok, őssejtvonalak az ADME kutatásban (Farmakokinetika és gyógyszermetabolizmus szimpózium, 2010. április 14-16., Galyatető, Hungary).

Polgár Zs, Tar K, Rungarunlert S, Muenthaisong S, Bock I, Pirity M, Dinnyés A. (2009) Generation of new C57B1/6J mouse embryonic stem cell lines. XV. Sejt- és Fejlődésbiológiai Napok, Nyíregyháza, 2009. április 17-19.p 142.

EU FP7 “Research Connections” Conference 7-8. May 2009. Prague Exhibition: Stand nr 31 MyScience – poster on display.

ISSCR 7th Annual Meeting, Improved Derivation of embryonic stem cell lines from inbred c57bl/6j mouse strains, Barcelona, Spain, July 8-11, 2009.

Costanza Emanueli

Mitic T, Emanueli C. (2012) Diabetes-induced epigenetic signature in vascular cells. Endocr Metab Immune Disord Drug Targets. Epub ahead of print

Caporali A, Meloni M, Völlenkle C, Bonci D, Sala-Newby GB, Addis R, Spinetti G, Losa S, Masson R, Baker AH, Agami R, le Sage C, Condorelli G, Madeddu P, Martelli F, Emanueli C. (2011) Deregulation of microRNA-503 contributes to diabetes mellitus-induced impairment of endothelial function and reparative angiogenesis after limb ischemia. Circulation, 123(3):282-91.

Vadim Fraifeld

Budovsky A, Shteinberg A, Maor H, Duman O, Yanai H, Wolfson M, Fraifeld V. (2013). Uncovering the Geroprotective Potential of Medicinal Plants from the Judea Region (Israel). Rejuvenation Res., doi: 10.1089/rej.2013.1509

Moskalev AA, Shaposhnikov MV, Plyusnina EN, Zhavoronkov A, Budovsky A, Yanai H, Fraifeld VE. (2013). The role of DNA damage and repair in aging through the prism of Koch-like criteria. Ageing Res Rev., 126:661-684.

Budovsky A, Craig T, Wang J, Tacutu R, Csordas A, Lourenço J, Fraifeld VE, de Magalhăes JP. (2013). LongevityMap: a database of human genetic variants associated with longevity. Trends Genet., 10: 559-560.

Tacutu R, Craig T, Budovsky A, Wuttke D, Lehmann G, Taranukha D, Costa J, Fraifeld VE, de Magalhăes JP. (2013). Human Ageing Genomic Resources: integrated databases and tools for the biology and genetics of ageing. Nucleic Acids Res., 41(Database issue):D1027-1033.

Tacutu R, Shore DE, Budovsky A, de Magalhăes JP, Ruvkun G, Fraifeld VE, Curran SP. (2012). Prediction of C. elegans longevity genes by human and worm longevity networks. PLoS One, 7:e48282.

Taranukha D, Budovsky A, Gobshtis N, Braiman A, Porat Z, Aronov S, Fraifeld VE. (2012). Co-regulation of polar mRNA transport and lifespan in budding yeast Saccharomyces cerevisiae. Cell Cycle, 11:4275-4280.

Moskalev AA, Smit-McBride Z, Shaposhnikov MV, Plyusnina EN, Zhavoronkov A, Budovsky A, Tacutu R, Fraifeld VE. (2012) Gadd45 proteins: Relevance to aging, longevity and age-related pathologies. Ageing Res Rev., 11:51-66.

Tacutu R, Budovsky A, Yanai H, Fraifeld VE. (2011) Molecular links between cellular senescence, longevity and age-related diseases - a systems biology perspective. Aging (Albany NY), [Epub ahead of print].

Yanai H, Budowsky A, Tacutu R, Fraifeld VE. (2011) Is rate of skin wound healing associated with aging or legevity phenotype? Biogerontology ISSN 1389-5729. (Download)

Budovsky A, Fraifeld VE, Aronov S. (2011) Linking cellpolarity, aging and rejuvenation. Biogerontology 12:167-175.

Budovsky A, Tacutu R, Wolfson M, Fraifeld VE. (2010) MicroRNA-regulated protein–protein interaction networks: how could they help in searching for pro-longevity targets? Rejuvenation Res., 13,373-377.

Tacutu R, Budovsky A, Fraifeld VE. (2010) The NetAge database: a compendium of networks for longevity, age-related diseases and associated processes. Biogerontology, 11:513-522.

Tacutu R, Budovsky A, Fraifeld V. The NetAge database (http://netage-project.org). (2009) Publicly available online since June 15, 2009.

Wolfson M, Budovsky A, Tacutu R, Fraifeld V. (2009) The signaling hubs at the crossroad of longevity and age-related disease networks. Int J Biochem Cell Biol., 41(3):516-20.

Wolfson M, Tacutu R, Budovsky A, Aizenberg N, Fraifeld V.E. (2008) MicroRNAs: Relevance to aging and age-related diseases. Open Longevity Science, 2, 66-75.

Wolfson M, Tacutu R, Budovsky A, Aizenberg N, Fraifeld VE. (2008) Common epigenetic mechanisms of aging and age-related diseases: the role for microRNAs. Probl Aging Longevity, 17, 184-201.

de Magalhaes JP, Budovsky A, Costa C, Lehmann G, Fraifeld V, Church GM. (2009) The Human Ageing Genomic Resources: online tools for gerontology. Aging Cell., 8,65-72.

Marcin Golec

Golec M, Skórska C, Lemieszek M, Dutkiewicz J. (2009) A Novel Inhalation Challenge Set to Study Animal Model of Allergic Alveolitis. Ann Agric Environ Med., 16, 173–175.

Francois Huaux

van den Brule S, Huaux F, Uwambayinema F, Ibouraadaten S, Yakoub Y,Palmai-Pallag M, Trottein F, Renauld JC, Lison D. (2013). Lung Inflammation and Thymic Atrophy After Bleomycin are Controlled by the PGD2 Receptor DP1. Am J Respir Cell Mol Biol., [Epub ahead of print].

Huaux F, Noel S, Dhooghe B, Panin N, Lo Re S, Lison D, Wallemacq P, Marbaix E, Scholte BJ, Lebecque P, Leal T. (2013). Dysregulated proinflammatory and fibrogenic phenotype of fibroblasts in cystic fibrosis. PLoS One., 29;8(5):e64341.

Lo Re S, Lison D, Huaux F. (2013). CD4+ T lymphocytes in lung fibrosis: diverse subsets, diverse functions. J Leukoc Biol., 93(4):499-510.

Lubamba B, Huaux F, Lebacq J, Marbaix E, Dhooghe B, Panin N, Wallemacq P, Leal T. (2012). Immunomodulatory activity of vardenafil on induced lung inflammation in cystic fibrosis mice. J Cyst Fibros., 11(4):266-73.

Lo Re S, Lecocq M, Uwambayinema F, Yakoub Y,  Delos M, Demoulin JB, Lucas S,  Sparwasser T, Renauld JC, Lison D, Huaux F. (2011) Platelet-Derived Growth Factor–Producing CD4+ Foxp3+ Regulatory T Lymphocytes Promote Lung Fibrosis. Am J Respir Crit Care Med. 184(11):1270-81.

Gasse P, Riteau N, Vacher R, Michel ML, Fautrel A, di Padova F, Fick L,Charron S, Lagente V, Eberl G, Le Bert M, Quesniaux VF, Huaux F, Leite-de-Moraes M, Ryffel B, Couillin I. (2011) IL-1 and IL-23 mediate early IL-17A production inpulmonary inflammation leading to late fibrosis. PLoS One. 6(8):e23185.

Rabolli V, Lo Re S, Uwambayinema F, Yakoub Y, Lison D, Huaux F. (2011) Lung fibrosis induced by crystalline silica particles is uncoupled from lung inflammation in NMRI mice. Toxicol Lett. 10;203(2):127-34.

van den Brule S, Wallemme L, Uwambayinema F, Huaux F, Lison D. (2010) The D prostanoid (DP) receptor agonist BW245C ((4S)-(3-[(3R,S)-3-cyclohexyl-3-hydroxypropyl]-2,5-dioxo)-4-imidazolidineheptanoi c acid) inhibits fibroblast proliferation and bleomycin-induced lung fibrosis in mice. J Pharmacol Exp Ther., 335(2), 472-9.

Giordano G, van den Brűle S, Lo Re S, Triqueneaux P, Uwambayinema F, Yakoub Y, Couillin I, Ryffel B, Michiels T, Renauld JC, Lison D, Huaux F. (2010) Type I interferonsignaling contributes to chronic inflammation in a murine model of silicosis. Toxicol Sci., 116(2),682-92.

Lo Re S, Dumoutier L, Couillin I, Van Vyve C, Yakoub Y, Uwambayinema F, Marien B, van den Brűle S, Van Snick J, Uyttenhove C, Ryffel B, Renauld JC, Lison D, Huaux F. (2010) IL-17A-producing gammadelta T and Th17 lymphocytes mediate lung inflammation but not fibrosis in experimental silicosis. J Immunol., 184(11), 6367-77.

David Benjamin Lumenta

Lumenta DB, Kamolz LP, Selig HF, Keck M, Frey M. (2012). Clinical data acquisition of wounds and scars using a handheld three-dimensional stereophotographic system: first experiences, Journal of Wound Technology 15: 59.

Lumenta DB, Selig H, Kitzinger HB, Kamolz LP. (2012). Objective quantification of wrinkles: three-dimensional analysis of surface irregularity, Plast Reconstr Surg 129(4):735e-7e.

Lumenta DB, Selig HF, Kitzinger HB, Kamolz LP. (2012). Objective quantification of subjective parameters in scars by use of a portable stereophotographic system, Ann Plast Surg 67(6):641-5.

Lumenta DB, Selig H, Kitzinger HB, Kamolz LP. (2011) Objective quantification of wrinkles: three-dimensional analysis of surface irregularity.  Plast Reconstr Surg., 129(4):735e-7e.

Lumenta DB, Selig HF, Kitzinger HB, Kamolz LP. (2011) Objective quantification of subjective parameters in scars by use of a portable stereophotographic system. Ann Plast Durg., 67(6):641-5.

Paolo Madeddu

S. Amadesi; C. Reni; R. Katare; M. Meloni; A. Oikawa; A. P. Beltrami; E. Avolio E; D. Cesselli; O. Fortunato; G. Spinetti; R. Ascione; E. Cangiano; M. Valgimigli; S.P. Hunt; C. Emanueli; P. Madeddu (2012) Role for Substance-P Based Nociceptive Signaling in Progenitor Cell Activation and Angiogenesis during Ischemia In Mice and in Human Subjects. Circulation;125(14):1774-86.

Katare R, Riu F, Mitchell K, Gubernator M, Campagnolo P, Cui Y, Fortunato O, Avolio E, Cesselli D, Beltrami AP, Angelini G, Emanueli C, Madeddu P. (2011) Transplantation of human pericyte progenitor cells improves the repair of infarcted heart through activation of an angiogenic program involving micro-RNA-132. Circ Res., 109(8):894-906.

Caporali A, Meloni M, Völlenkle C, Bonci D, Sala-Newby GB, Addis R, Spinetti G, Losa S, Masson R, Baker AH, Agami R, le Sage C, Condorelli G, Madeddu P, Martelli F, Emanueli C.(2011) Deregulation of microRNA-503 contributes to diabetes mellitus-induced impairment of endothelial function and reparative angiogenesis after limb ischemia. Circulation, 123(3):282-91.

Katare R, Caporali A, Zentilin L, Avolio E, Sala-Newby G, Oikawa A, Cesselli D, Beltrami AP, Giacca M, Emanueli C, Madeddu P. (2011) Intravenous Gene Therapy With PIM-1 Via a Cardiotropic Viral Vector Halts the Progression of Diabetic Cardiomyopathy Through Promotion of Prosurvival Signaling. Circ. Res., 108: 1238-1251.

Katare R, Caporali A, Emanueli C, Madeddu P. (2010) Benfotiamine improves functional recovery of the infarcted heart via activation of pro-survival G6PD/Akt signaling pathway and modulation of neurohormonal response. J Mol Cell Cardiol., 49(4):625-38.

Katare RG, Caporali A, Oikawa A, Meloni M, Emanueli C, Madeddu P. (2010) Vitamin B1 analog benfotiamine prevents diabetes-induced diastolic dysfunction and heart failure through Akt/Pim-1-mediated survival pathway. Circ Heart Fail., 294-305.

Barcelos LS, Duplaa C, Kränkel N, Graiani G, Invernici G, Katare R, Siragusa M, Meloni M, Campesi I, Monica M, Simm A, Campagnolo P, Mangialardi G, Stevanato L, Alessandri G, Emanueli C  and Madeddu P. (2009) Human stem cells promote healing of diabetic ulcers. Circ Res., 104(9):1095-102.

Wolfgang Mikulits

Haider C, Grubinger M, Reznícková E, Weiss TS, Rotheneder H, Miklos W, Berger W, Jorda R, Zatloukal M, Gucky T, Strnad M, Krystof V, and Mikulits, W. (2013). Novel Inhibitors of Cyclin-Dependent Kinases Combat Hepatocellular Carcinoma without Inducing Chemoresistance. Mol. Cancer Ther., [Epub ahead of print].

Kopf, S., Viola, K., Atanasov, A.G., Jarukamjorn, K., Rarova, L., Kretschy, N., Teichmann, M., Vonach, C., Saiko, P., Giessrigl, B., Huttary, N., Raab, I., Krieger, S., Schumacher, M., Diederich, M., Strnad, M., de Martin, R., Szekeres, T., Jäger, W., Dirsch, V.M., Mikulits, W., Grusch, M., Dolznig, H. and Krupitza, G. (2013). In vitro characterisation of the anti-intravasative properties of the marine product heteronemin. Arch. Toxicol., [Epub ahead of print]

Viola. K., Kopf, S., Rarova, L., Jarukamjorn, K., Kretschy, N., Teichmann, M., Vonach, C., Atanasov, A.G., Giessrigl, B., Huttary, N., Raab, I., Krieger, S., Strnad, M., de Martin, R., Saiko, P., Szekeres, T., Knasmüller, S., Dirsch, V.M., Jäger, W., Grusch, M., Dolznig, H., Mikulits, W. and Krupitza G. (2013). Xanthohumol attenuates tumour cell-mediated breaching of the lymphendothelial barrier and prevents intravasation and metastasis. Arch Toxicol., 87: 1301-1312.

Kretschy, N., Teichmann, M., Kopf, S., Atanasov, A.G., Saiko, P., Vonach, C., Viola, K., Giessrigl, B., Huttary, N., Raab, I., Krieger, S., Jäger, W., Szekeres, T., Nijman, S.M., Mikulits, W., Dirsch, V.M., Dolznig, H., Grusch, M. and Krupitza, G. (2013). In vitro inhibition of breast cancer spheroid-induced lymphendothelial defects resembling intravasation into the lymphatic vasculature by acetohexamide, isoxsuprine, nifedipin and proadifen. Br. J. Cancer., 108: 570-578.

Viola, K., Kopf, S., Huttary, N., Vonach, C., Kretschy, N., Teichmann, M., Giessrigl, B., Raab, I., Stary, S., Krieger, S., Keller, T., Bauer, S., Hantusch, B., Szekeres, T., de Martin, R., Jäger, W., Mikulits, W., Dolznig, H., Krupitza, G. and Grusch M. (2013). Bay11-7082 inhibits the disintegration of the lymphendothelial barrier triggered by MCF-7 breast cancer spheroids; the role of ICAM-1 and adhesion. Br. J. Cancer., 108: 564-569.

Sancho, P., Mainez, J., Crosas, E., Roncero, C., Fernández-Rodriguez, C.M., Pinedo, F., Huber, H., Eferl, R., Mikulits, W. and Fabregat, I. (2012). NADPH oxidase NOX4 mediates stellate cell activation and hepatocyte cell death during liver fibrosis development. PLos One, 7(9):e45285.

Reichl, P., Haider, C., Grubinger, M. and Mikulits, W. (2012). TGF-β in Epithelial to Mesenchymal Transition and Metastasis of Hepatocellular Carcinoma. Curr. Pharm. Des., 18: 4135-4147.

van Zijl, F., Krupitza, G. and Mikulits, W. (2011) Initial steps of metastasis:Cell invasion and endothelial transmigration. Mut. Res., 728, 23-34.
 
Vonach, C., Viola, K., Giessrigl, B., Huttary, N., Raab, I., Kalt, R., Krieger, S., Vo, T.P.N., Madlener, S., Bauer, S., Marian, B., Hämmerle, M., Kretschy, N., Teichmann, M., Hantusch, B., Stary, S., Unger, C., Seelinger, M., Eger, A., Mader, R., Jäger, W., Schmidt, W., Grusch, M., Dolznig, H., Mikulits, W., and Krupitza, G. (2011) NF-kB mediates the 12(S)-HETE-induced endothelial to mesenchymal transition of lymphendothelial cells during the intravasation of breast carcinoma cells. Br. J. Cancer, 105, 263-271.

Schneller, D., Machat, G., Sousek, A., Proell, V., van Zijl, F., Zulehner, G., Huber, H., Mair, M., Muellner, M.K., Nijman, S.M.B., Eferl, R., Moriggl, R. and Mikulits, W. (2011) p19ARF/p14ARF controls oncogenic functions of Stat3 in hepatocellular carcinoma. Hepatology, 54, 164-172.

Grusch M, Petz M, Metzner T, Öztürk D, Schneller D, Mikulits W, (2010) The Crosstalk of RAS with the TGF-β Family during Carcinoma Progression and its Implications for Targeted Cancer Therapy. Current Cancer Drug Targets, 10(8):849-57.

van Zijl F, Mikulits W. (2010) Hepatospheres: Three dimensional cell cultures resemble physiological conditions of the liver. World J. Hepatol., 2. 1-7.

van Zijl F, Zulehner G, Petz M, Schneller D, Kornauth C, Hau M, Machat G, Grubinger M, Huber H, Mikulits W. (2009) Epithelial to mesenchymal transition in hepatocellular carcinoma. Future Oncology, 5, 1169-1179.

van Zijl F, Mair M, Csiszar A, Schneller D, Zulehner G, Huber H, Eferl R, Beug H, Dolznig H, Mikulits W. (2009) Hepatic Tumor-Stroma Crosstalk Guides Epithelial to Mesenchymal Transition at the Tumor Edge. Oncogene, 28:4022-4033.

Macheiner D, Gauglhofer C, Rodgarkia-Dara C, Grusch M, Brachner A, Bichler C, Kandioler D, Sutterlüty H, Mikulits W, Schulte-Hermann R, Grasl-Kraupp B. (2009) NORE1B is a putative tumor suppressor in hepatocarcinogenesis and may act via RASSF1A. Cancer Res., 69, 235-242.

Lahsnig C, Mikula M, Petz M, Zulehner G, Schneller D, van Zijl F, Huber H, Csiszar A, Beug H, Mikulits W. (2009) ILEI requires oncogenic Ras for the epithelial to mesenchymal transition of hepatocytes and liver carcinoma progression. Oncogene, 28, 638-650.

Probst OC, Puxbaum V, Svoboda B, Leksa V, Stockinger H, Mikula M, Mikulits W, Mach L. (2009) The mannose 6-phosphate/insulin-like growth factor II receptor restricts the tumourigenicity and invasiveness of squamous cell carcinoma cells. Int. J. Cancer, 124, 2559-2567.

Winter HK, Ehrlich VA, Grusch M, Lackner A, Schulte-Hermann R, Grasl-Kraupp B, Mikulits W, Knasmüller S. (2008) Use of four new human-derived liver-cell lines for the detection of genotoxic compounds in the single-cell gel electrophoresis (SCGE) assay. Mutat. Res., 657, 133-139.

Sagmeister S, Eisenbauer M, Pirker C, Mohr T, Holzmann K, Zwickl H, Bichler C, Kandioler D, Wrba F, Mikulits W, Gerner C, Shehata M, Majdic O, Streubel B, Berger W, Micksche M, Zatloukal K, Schulte-Hermann R, Grasl-Kraupp B. (2008) New cellular tools reveal complex epithelial-mesenchymal interactions in hepatocarcinogenesis. Br. J. Cancer, 99, 151-159.

Knasmüller S, Nersesyan A, Misík M, Gerner C, Mikulits W, Ehrlich V, Hoelzl C, Szakmary A, Wagner KH. (2008) Use of conventional and –OMICS based methods for health claims of dietary antioxidants: a critical overview. British J. Nutrition, E Suppl 1:ES3-52.

Christa Nöhammer und Klemens Vierlinger

 Wielscher M, Pulverer W, Peham J, Hofner M, Rappaport CF, Singer C, Jungbauer C, Nöhammer C, Weinhäusel A. (2011) Methyl-binding domain protein-based DNA isolation from human blood serum combines DNA analyses and serum-autoantibody testing. BMC Clin Pathol., 11:11.

G. Egger, M. Wielscher, W. Pulverer, A. Kriegner, A. Weinhäusel. (2012) DNA methylation testing and marker validation using PCR - diagnostic applications; Expert Review of Molecular Diagnostics, 12(1); S. 75 - 92.

I. Visne, E. Dilaveroglu, A Yildiz, K. Vierlinger, Ch. Nöhammer, F. Leisch, A. Kriegner. (2012) SpeedR: An R Package for Interactive Data Import, Filtering and Ready-to-Use Code Generation; Journal of Statistical Software, Vol. 51.

W. Pulverer, M. Wielscher, R. Panzer-Grünmayer, T. Plessl, A. Kriegner, K. Vierlinger, A. Weinhäusel. (2012) The stem cell signature of CHH/CHG methylation is not present in 271 cancer associated 5´UTR gene regions; Biochimie, 94 (2012), S. 2345 - 2352.

Perez-Riverol, Yasset; Hermjakob, Henning; Kohlbacher, Oliver; Martens, Lennart; Creasy, David; Cox, Jürgen et al. (2013) Computational proteomics pitfalls and challenges: HavanaBioinfo 2012 Workshop report. In: J Proteomics 87, S. 134–138. DOI: 10.1016/j.jprot.2013.01.019.

Wielscher M, Pulverer W, Peham J, Hofner M, Rappaport CF, Singer C, Jungbauer C, Nöhammer C, Weinhäusel A. (2011) Methyl-binding domain protein-based DNA isolation from human blood serum combines DNA analyses and serum-autoantibody testing. BMC Clin Pathol,11:11.

Almut Nebel and Friedericke Flachsbart

Carolin Däumer, Friederike Flachsbart, Amke Caliebe, Stefan Schreiber, Almut Nebel, Michael Krawczak. Adjustment for smoking does not alter the FOXO3A association with longevity. Age; accepted for publication.

Friederike Flachsbart, Amke Caliebe, Femke-Anouska Heinsen, Tom Hemming-Karlsen, Stefan Stefan Schreiber, Andre Franke, Almut Nebel. Investigation of complement component C4 copy number variation in human longevity. PLoS One, in revision.

Liljana Gentschew, Friederike Flachsbart, Rabea Kleindorp, Nandini Badarinarayan, Stefan Schreiber, Almut Nebel. Polymorphisms in the family of superoxidase dismutases reveal no association with human longevity in Germans. Biogerontology, in revision.

Flachsbart F, Caliebe A, Kleindorp R, Blanché H, von Eller-Eberstein H, Nikolaus S, Schreiber S, Nebel A. (2009) Association of FOXO3A variation with human longevity confirmed in German centenarians. Proc Natl Acad Sci U S A, 106(8), 2700-5.