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Resolve Chronic Inflammation and Achieve Healthy Ageing by Understanding Non-regenerative Repair

Effect of IFS on the new targets for fibroproliferative repair

Throughout its whole experimental phase, RESOLVE aims to characterise promising new targets in organ-specific in-vitro culture systems. Interfering biological substances (IFS) are specifically used for characterisation and validation of these targets.

IFS including promising small interfering (si)RNA and/or microRNAs are tested in cell cultures from skin of Lep -/- mice, hepatocytes of p19ARF -/- mice that have undergone EMT, fibroblasts from IPF lung tissue, and particularly in specific fibroproliferative transgenic animals. Changes of transcription profiles and protein expression profiles due to the action of siRNA are monitored. Full-scale transcriptomics and tailored transcription analysis are performed for assessment of differences in the signalling profile following intervention together with toponomics and proteome analysis.

Involvement


Wolfgang Mikulits (Medizinische Universitšt Wien) - workpackage-leader

Vadim Fraifeld (Ben-Gurion University of the Negev)
Francois Huaux (Universitť Catholique de Louvain)
Paolo Madeddu (University of Bristol)