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Resolve Chronic Inflammation and Achieve Healthy Ageing by Understanding Non-regenerative Repair

Research activities in Human Model Diseases

The basis for all human studies is a combination of careful clinical assessment of disease conditions and sequential analysis of biological data – to identify relevant molecular targets and separate them from those connected to regular organ repair. Studies relate to skin and lung manifestations including their vasculature.

Normal repair

Organs: skin
The initial human studies address skin repair after skin injury requiring surgical intervention for therapy in

  • young (21-35 years old) and
  • old individuals (age > 55 years)

Inflammatory repair

Organs: skin, lung
RESOLVE analyses inflammatory repair conditions of the following disease conditions:

  • surgical wounds and burns w/o infection,
  • secondary wound healing in non-diabetic patients,
  • keloid formation in black Africans from South Africa and
  • pulmonary fibrosis due to inhalation of organic dusts (hypersensitivity pneumonitis)

Human studies include ex vivo-culture systems

Fibroproliferative repair

Organs: skin, lung
RESOLVE analyses the following diseases:

  • chronic hypertrophic scar formation in skin repair,
  • chronic wound healing in atherosclerotic skins tissue in patients with diabetes mellitus type 2, and
  • progressive organ fibrosis in the lung (idiopathic interstitial lung diseases including idiopathic pulmonary fibrosis; IPF)

Analytical screen results are statistically analysed, used for mathematical modelling, for literature searches and for exploration of suitable siRNAs and microRNAs.


Paolo Madeddu
(University of Bristol) - workpackage-leader

Lars Peter Kamolz (Medizinische Universität Wien)
Jacek Dutkiewicz (Institute of Agricultural Medicine)
Marcin Golec (Institute of Agricultural Medicine)
Lutz-Henning Block (Medizinische Universität Wien)